A study on the esophageal sensitivity to acid and carbonated water by modified acid perfusion test and carbonated water perfusion test in healthy volunteers and patients with gastroesophageal reflux disease

A study on the esophageal sensitivity to acid and carbonated water by modified acid perfusion test and carbonated water perfusion test in healthy volunteers and patients with gastroesophageal reflux disease - Esophageal sensitivity test to acid and carbonated water

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004005

Enrollment

Registered

2010-08-06

Start date

2010-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal reflux disease

Interventions

Distilled water and acid perfusion(More than 1 week)Distilled water and carbonated water perfusion Distilled water and carbonated water perfusion(More than 1 week)Distilled water and acid perfusion

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Healthy volunteers and patients with gastroesophageal reflux disease more than 18 years-old 2)Subjects with written informed consent

Exclusion criteria

Exclusion criteria: 1)Allegy for lidocaine 2)Past history of gastrectomy 3)The person who catch a clinically improper disease before study starting within 2 weeks 4)Severe diseases in heart, kidney, liver, nerve, digestive system,or severe mental disorder 5)other not applicable person recognized by a doctor

Design outcomes

Primary

Measure	Time frame
Evaluation of the digestive symptom (Visual analogue scale) during the perfusion test	—

Countries

Japan

Contacts

Public ContactKenji Furuta

Shimane University Faculty of Medicine Gastroenterology and Hepatology

0853-20-2190

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026