Recurrent malignant glioma
Conditions
Interventions
Convection-enhanced delivery of ACNU
Sponsors
Department of Neurosurgery, Tohoku University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Pathological diagnosis of recurrent malignant glioma. In case of brainstem gliomas, clinical diagnosis of diffuse brain stem glioma or malignant glioma should be sufficient. 2) Recurrent cases after standard therapy. 3) Inoperable cases or cases that refused surgical resection. 4) No treatment within 4 weeks before this study. 5) 6 years old or elder. 6) No systemic complication. 7) Informed consent is required.
Exclusion criteria
Exclusion criteria: 1) Cases suffering active cancer 2) Cases suffering meningitis or pneumonia 3) Pregnant or breast feeding woman 4) Karnofsky performance status score less than 30 5) Cases suffering active inflammation 6) Cases with severe liver dysfunction 7) Cases with bone marrow insufficiency 8) Cases with renal failure 9) Cases with hemorrhagic diathesis 10) Cases taking anti-coagulative or anti-platelet agents 11) Cases with psychological diseases 12) Cases with uncontrolled Diabetes Mellitus 13) Cases suffered myocardial infarction within 3 months or cases with unstable angina 14) Cases that have history of pulmonary fibrosis or interstitial pneumoniae
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Toxicity Response of targeted lesion | — |
Secondary
| Measure | Time frame |
|---|---|
| Best overall response | — |
Countries
Japan
Contacts
Public ContactRyuta Saito
Tohoku University Graduate School of Medicine Department of Neurosurgery
Outcome results
None listed