Hypertension
Conditions
Interventions
Administration of dose-up of candesartan (from 8mg to 12mg/day) for 6 months
Additional adminstration of 6.25mg/day of hydrochlorothiazide for 6 months
Sponsors
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with essential hypertension who has the insufficient values of blood pressure under taking antihypertensive agents except diuretics and additional administration of 8mg/day of candesartan for at least 3 months are enrolled. Incrusion criteria included the following: (1)Patients in outpatient clinic (2)Male or female of more than 40 years (3)Patients with more than 135 mmHg in systolic blood pressure or 85 mmHg in diastolic blood pressure on 2 times of most recent measurements of blood pressure at sitting position (4)Patients who agreed to attend to this study
Exclusion criteria
Exclusion criteria: Exclusion criteria comprised any of the following: (1)Patients under treatments with antihypertensive agents except diuretics who will not continue to take 8mg/day of candesartan for at least 3 months. (2)Administration of diuretics or of agents influencing rennin-angiotensin-aldosterone system except for candesartan. (3)Concomitant medications which are expected to be frequently changed. (4)Under treatment of insulin for diabetes. (5)Severe renal dysfunction (eGFR<30 mL/min/1.73m2) (6)Heart failure (NYHA classification III or IV) (7)Malignant hypertension and secondary hypertension. (8)Myocardial infarction, stroke, and revascularization therapies of coronary arteries and/or peripheral arteries within 6 months prior to the registration of this study. (9)Pregnant female (10)Allergic disorder which is problem in the clinical setting. Hypersensitivity or contraindication to candesartan or hydrochlorothiazide. (11)Patients who are judged by doctors as inappropriate patients for the entries of this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in blood pressure values in outpatient clinic. Changes in the levels of urine microalbumin, NT-proBNP, high-sensitive CRP, and HbA1c. | — |
Secondary
| Measure | Time frame |
|---|---|
| Flow mediated dilation Augmentation index | — |
Countries
Japan
Contacts
Public ContactSatoshi Ikeda
Nagasaki University Graduate School of Biomedical Sciences Department of Cardiovascular Medicine
Outcome results
None listed