Moderate and severe pneumonia
Conditions
Interventions
Elderly patients (50 cases) aged 65 and over with moderate and severe pneumonia, treated with Biapenem 0.3g three times daily for less than 2 weeks during the period of July 2010 to May 2011
Sponsors
Fuji Heavy Industries Ltd Health Insurance Society Ota Hospital: Neurology, Ashikaga Red Cross Hospital :Respiratory internal medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Elderly patients aged 65 and over regardless of underlying disease. Severity levels of pneumonia are classified by the severity criteria according to "Guidelines for the management of respiratory infections, 2008" edited by The Japanese Respiratory Society.
Exclusion criteria
Exclusion criteria: (1)Cases with severe cardiac, hepatic, renal function disorder(2)Cases with a history of allergy to B-lactam antibiotics(carbapenems,cephems,penicillins,etc.)(3)Cases which therapeutic response of B-lactam antibiotics can't be expected(caused by virus,mycoplasma,chlamydia and fungus)(4)Cases treated with sodium valproate(5)Cases with improvement by previous treatment of antimicrobial agent(6)Cases with similar infectious episode of ineffective treatment with carbapenem antibiotics(7)Other cases which doctor in charge regard inadequate to include in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of clinical response after 3 days administration, clinical response at the end of treatment, bacteriological response, serum concentration measurement and PK-PD analysis | — |
Countries
Japan
Contacts
Public ContactMitsuru Sando
Fuji Heavy Industries Ltd Health Insurance Society Ota Hospital Pharmaceutical Department
Outcome results
None listed