Intraocular lymphoma
Conditions
Interventions
5 cycles of systemic methotexate every 2 weeks after intravitreal methotrexate injection
Sponsors
Tokyo Medical and Dental University, Department of Hematology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: A. Patients of intraocular lymphoma without CNS involvement (examined by CT scan, MRI and lumbar puncture), diagnosed according to the following criteria: 1) positive for characteristic ocular symptoms and findings of lymphoma 2) pathologically diagnosed as lymphoma 3) positive for IgH gene clonality detected by PCR assay or flow cytometry 1 with 2 or 3 B. Patients whose written informed consent can be obtained
Exclusion criteria
Exclusion criteria: (1) Lymphoma with extra-CNS involvement (2) Women during pregnancy (3) History of serious allergic reactions, for example, asthma, urticaria, etc. by medical agents (4) Contraindication for methotrexate (a) History of serious adverse reactions by methotrexate (b) Severe dysfunction of liver, kidney, and heart (c) Pleural effusion or ascites except for those with little amount, which cannot be performed pleural or abdominal puncture
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2 years disease free survival | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of adverse events, and relapse rate (intraocular, central nerve system and other lesion) | — |
Countries
Japan
Contacts
Public ContactMinako Jinta
Tokyo Medical and Dental University Department of Hematology
Outcome results
None listed