Comparison of blood pressure lowering effect of amlodipine between once-a-daily administration and twice-a-daily administration

Comparison of blood pressure lowering effect of amlodipine between once-a-daily administration and twice-a-daily administration - Comparison of blood pressure lowering effect of amlodipine between once-a-daily administration and twice-a-daily administration

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003914

Enrollment

Registered

2010-07-16

Start date

2010-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Essential hypertension

Interventions

After 2 months of treatment with amlodipine 5mg twice a daily, the same patient will be treated with amlodipine 10mg once a daily.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Outpatients with essential hypertension who are treated with amlodipine 5mg twice a daily

Exclusion criteria

Exclusion criteria: 1. Patients with secondary hypertension 2. Patients with SBP 150 mmHg or greater,or DBP 100 mmHg or greater. 3. Patients with malignant hypertension 4. Patients who were hospitalized because of stroke, myocadial infarction or vascular diseases within 6 months. 5. Patients with atrial fibrillation. 6. Patients with elevated liver enzymes. (AST or ALT is more than 2.5 times as high as upper normal limit) 7. Patients with elevated serum creatinine (2.0mg/dL or greater) 8. Pregnant or nursing women 9. Patients who are considered as inappropriate to participants for this study by attending physician

Design outcomes

Primary

Measure	Time frame
Difference in 24 h mean blood pressure between the treatment with amlodipine 10mg once a daily and amlodipine 5mg twice a daily	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026