Effects of epidural analgesia and peripheral nerve block on postoperative analgesia and early knee rehabilitation after total knee arthroplasty

Effects of epidural analgesia and peripheral nerve block on postoperative analgesia and early knee rehabilitation after total knee arthroplasty - Effects of epidural analgesia and peripheral nerve block on postoperative analgesia and early knee rehabilitation after total knee arthroplasty

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003910

Enrollment

Registered

2010-07-15

Start date

2010-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients scheduled for elective unilateral total knee arthroplasty under general anesthesia

Interventions

&lt

Group CFNB(continuous femoral nerve block)&gt

Preoperative insertion of continuous femoral nerve block catheter and injection of 0.3% ropivacaine 60mg for continuous femoral nerve block and single-shot sciatic nerve block at the operative side (

Group CEI(continuous epidural infusion)&gt

Preoperative insertion of epidural catheter at L3/4. Injection of 0.3% ropivacaine 90mg during surgery. Postoperative continuous infusion of 0.15% ropivacaine 4mL/h for 60 hours.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients scheduled unilateral total knee arthroplasty at Osaka University Medical Hospital.

Exclusion criteria

Exclusion criteria: Inability to communicate lucidly. Revision knee arthroplasty. Chronic pain syndrome unrelated to knee pathology. Allergy to local anesthetics. ASA phisical status above III. Chronic opioid use. Severe diabetes mellitus with sensory disorder. Neurologically-disabled. Contraindications to epidural analgesia or peripheral nerve block.

Design outcomes

Primary

Measure	Time frame
Day of knee flexion achievement above 120 degrees	—

Secondary

Measure	Time frame
Efficacy of postoperative pain management(VAS evaluation), Thigh and calf circumrefence, Rate of side effect Rehabilitation milestone(Ambulation with a cane, range of motion of operative knee) Frequency of Additional analgesia	—

Countries

Japan

Contacts

Public ContactNorihiro Sakai

Osaka University Graduate School of Medicine Department of Anesthesia and Intensive Care Medicine

sakayline@gmail.com06-6879-3133

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026