Obesity hypertension
Conditions
Interventions
Combination of western medicine and oriental herbal medicine group: In addition to western anti-hypertensive therapy including diet and exercize therapy, an oriental herbal medicine Bofu-tsusho-san i
Sponsors
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Essential hypertensive (male and female) patients with obesity under anti-hypertensive treatments including diet and exercise therapy for more than 4 weeks. Other selection criteria; 1. Age >=20 years old, but < 80 years old. 2. BMI >= 25 kg/m2. 3. Written informed consent obtained.
Exclusion criteria
Exclusion criteria: Exclusion criteria; 1. Age < 20 years old or >= 80 years old. 2. Pregnant women, nursing women, or women suspected of being pregnant. 3. Secondary hypertension, maliganant hypertension, or grade III hypertension (SBP >= 180 mmHg or DBP >= 110 mmHg) 4. Hyperthyroidism. 5. History of coronary artery disease or cerebral artery disease with 6 months. 6. Judged as inappropriate for study by doctor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ambulatory blood pressure (BP) profiles (mean BP, diurnal BP profile, base BP, BP variability) at baseline and after 3 and 6 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Body weight, BMI, abdominal circumference, glucose metabolism (FBG, HbA1c, HOMA-IR, IRI, adiponectin, resistin), lipid metabolism (T-cho, LDL-cho, HDL-cho, TG), oxidative stress (MDA-LDL-cho, pentosidine, urinary L-FABP), urinary angiotensinogen, renal function (urinary albumin excretion, urinary protein excretion, estimated GFR), blood electrolyte (sodium, potassium, chloride), baPWV, episode of cardiovascular disease, and adverse effects. | — |
Countries
Japan
Contacts
Public ContactKOUICHI TAMURA
Yokohama City University Graduate School of Medicine Department of Medical Science and Cardiorenal Medicine
Outcome results
None listed