Intrarenal RAAS Activity can Modify Circadian Blood Pressure Rhythm in CKD

Intrarenal RAAS Activity can Modify Circadian Blood Pressure Rhythm in CKD - Intrarenal RAAS & Non-dipper

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000003870

Enrollment

Registered

2010-07-08

Start date

2010-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease (CKD)

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The subjects were patients with CKD, who underwent renal biopsy, 24h-ABPM, and urinary sampling for daytime and night-time under hospitalization at Nagoya City University Hospital.

Exclusion criteria

Exclusion criteria: 1) Usage of antihypertensive agents, imcluding diuretics and RAAS inhibitors. 2) Increase in the dosages of steroids or immunosuppressor for 2 months before renal biopsy 3) Nephrotic syndrome with severe edema

Design outcomes

Primary

Measure	Time frame
Examine whether subjects with non-dipper rhythms of BP and natriuresis showed increased AGT expression in renal biopsy specimens (especially in proximal tubules) accompanied by enhanced tubular sodium reabsorption in patients with CKD.	—

Secondary

Measure	Time frame
24h BPs, glomerular filtration rate (GFR)	—

Countries

Japan

Contacts

Public ContactMichio Fukuda

Nagoya City University Cardio-Renal Medicine and Hypertension

m-fukuda@med.nagoya-cu.ac.jp+81-52-853-8221

Outcome results