Atrial fibrillation
Conditions
Interventions
Carvedilol 2.5-20 mg/day, 3 months
Bisoprolol 2.5-5 mg/day, 3 months
Sponsors
Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patient who has either of chronic atrial fibrillation and hypertension. 2) Patients who are aged 20 years or older and less than 75 years at the entry. 3) Patients who have administred carvedilol or bisoprolol over 3 months. 4) Patients with left ventricular ejection fraction > 40%, and without decompensated heart failure.
Exclusion criteria
Exclusion criteria: 1) Patients with contraindication to betablockers. 2) Patients with a history of unstable angina pectoris or myocardial infarction within 3 months. 3) Judgment by attending physician that patient participation would be inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Subjective symptom: Frequency of palpitation 2. Objective symptom: New York Heart Association (NYHA) classification of cardiac performance, BP, HR 3. Laboratory test: Blood biochemical findings include BNP 4. Physiological laboratory: ambulatory electrocardiography, cardiac ultrasonography 5. Adverse event | — |
Countries
Japan
Contacts
Public ContactHiroaki Obata
Niigata University Graduate School of Medical and Dental Sciences Division of Cardiology
Outcome results
None listed