Smoker
Conditions
Interventions
High-absorptive Curcumin 30mg/day po for 12 weeks
Sponsors
National Hospital Organization Kyoto Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Smokers who tried to but could not quit smoking after standard smoking cessation program at Smoking Cessation Clinic. 2. Smokers who will not quit smoking.
Exclusion criteria
Exclusion criteria: 1) Unstable angina, recent (< 3 months) myocardial infarction, severe coronary heart disease (left main trunk or 3 vessel disease), and recent (=< 3 months) orplanned (=< 6 months) AC bypass surgery / PCI 2) Severe arrhythmia (sustained ventricular tachycardia, ventricular fibrillation, and severe bradycardia with an indication of pacemaker implantation 3) Moderate or severe valvular diseases 4) Cardiomyopathy or progressive myocarditis 5) Severe respiratory diseases 6) Cardiogenic shock or systolic blood pressure < 80 mmHg 7) Renal failure (Cre >= 4.0 mg/dL or dialysis) 8) Severe liver dysfunction or liver cirrhosis 9) Recent (< 3 months) cerebrovascular disease 10) Malignancy 11) Poorly controlled diabetes (HbA1c >= 8.0%) 12) Anemia (Hb < 6.0 mg/dL) 13) Use of steroid 14) Past history of Curcumin allergy 15) Pregnancy, nursing, or a wish for pregnancy within 6 months 16) etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum levels of oxidative stress markers | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of possible novel biomarkers of cardiovascular risk | — |
Countries
Japan
Contacts
Public ContactKoji Hasegawa
National Hospital Organization Kyoto Division of Translational Research
Outcome results
None listed