Preventing postoperative nausea and vomiting: Effect of Neurokinin-1 receptor antagonist

Preventing postoperative nausea and vomiting: Effect of Neurokinin-1 receptor antagonist - Preventing postoperative nausea and vomiting: Effect of Neurokinin-1 receptor antagonist

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003850

Enrollment

100

Registered

2010-07-02

Start date

2010-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative nausea and vomiting

Interventions

Patients received general anesthesia for abdominal surgery of gynaecology assign Aprepitant group to Control group in a randmized. On the day of surgery,Aprepitant group takes orally Aprepitant 80mg

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Eligible patients are between 20-70 years old who met the criteria of the American Society of Anesthesiologists(ASA) physical status of 1-3,and are scheduled for abdominal surgery of gynaecology requiring an overnight hospital stay.

Exclusion criteria

Exclusion criteria: Patiens are excluded the criteria of the American Society of Anesthesiologists(ASA) physical status of over 3 neurotic disease,kidney disorder,hepatic disorder and taked antiemetic drugs.Further,excluded contraindication of Aprepitant(an anamnesis of hypersensitivity and taked Pimozide).

Design outcomes

Primary

Measure	Time frame
frequency of the PONV	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026