Effect of AT1 receptor blocker plus low-dose diuretics and Ca blocker on home blood pressure

Effect of AT1 receptor blocker plus low-dose diuretics and Ca blocker on home blood pressure - PLES TRIAL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003847

Enrollment

Registered

2010-06-30

Start date

2010-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

Preminent treated group (Losartan50mg+Hydrochrolthiazide12.5mg) Olmesartan 20mg+Calblock16mg

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Hypertension over 140/90 mmHg at Office

Exclusion criteria

Exclusion criteria: Secondary Hypertension CVD within 6 months Ischemic heart disease within 6months Heart failure over NYHA III Severe Liver disease Severe Kidney disease

Design outcomes

Primary

Measure	Time frame
Morning blood pressure	—

Secondary

Measure	Time frame
Evening blood pressure Office blood pressure Side effect	—

Countries

Japan

Contacts

Public ContactHidetomo Nakamoto

Saitama Medical University General Internal Medicine

nakamo_h@saitama-med.ac.jp049-276-1667

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026