A multicenter randomized double blind test of the effect of preoperative dexamethasone on postoperative nausea and vomiting after laparoscopic cholecystectomy

A multicenter randomized double blind test of the effect of preoperative dexamethasone on postoperative nausea and vomiting after laparoscopic cholecystectomy - A multicenter randomized double blind test of the effect of preoperative dexamethasone on postoperative nausea and vomiting after laparoscopic cholecystectomy

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003841

Enrollment

270

Registered

2010-06-29

Start date

2010-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases in the gallbladder

Interventions

Intravenous administration of dexamethasone (8mg) just before cholecystectomy Intravenous administration of saline just before cholecystectomy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Patient undergoing laparoscopic cholecystectomy (2) Age between 20 and 79 (3) Adequate hematologic, hepatic, renal and respiratory function (4) Written informed consent

Exclusion criteria

Exclusion criteria: (1) Emergency surgery (2) Patient who had undergone upper abdominal surgery (3) Patient who is expected to convert into open surgery (4) Continuous use of steroid (5) ASA>3 (6) Day surgery (7) Treatment with opioid or tranquilizer within 1 week (8) Clinically significant cardiac or respiratory dysfunction (9) Severe mental disorder (10) Contraindication for dexamethasone (11) As determined by the principal investigator or the sub-investigator the subject is not adequate to participate in the trial

Design outcomes

Primary

Measure	Time frame
The incidence of post operative nausea and vomiting (PONV)	—

Secondary

Measure	Time frame
Postoperative complications, Postoperative hospital stay, Medical cost	—

Countries

Japan

Contacts

Public ContactHidetoshi Eguchi

Osaka University Graduate school of Medicine Department of Gastroenterological Surgery

heguchi@gesurg.med.osaka-u.ac.jp06-6879-3251

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026