Severe sepsis
Conditions
Interventions
The patients with severe sepsis are treated following Surviving Sepsis Campaign guidelines 2008. Patients are randomly assigned to receive hANP or distilled water (placebo) for continuous infusion.
severe hypotension, drug allergy, anaphylaxis, severe organ failure and so on due to hANP. Severe hypotension is defined as mean arterial pressure will be less than 65mmHg and simultaneously re-admini
Dopamine (mcg/kg/min) + Dobutamine (mcg/kg/min) + Noradrenaline (mcg/kg/min) * 100)
The patients with severe sepsis are treated following Surviving Sepsis Campaign guidelines 2008. Distilled water
Dopamine (mcg/kg/min) + Dobutamine (mcg/kg/min) + Noradrenaline (mcg/kg/min) * 100)
Sponsors
Tosei General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The eligibility criteria for the study are age older 16 years and the presence of severe sepsis or septic shock. Patients, who have renal failure according to RIFLE category or are dependent on mechanical ventilation including non-invasive ventilation, are enrolled. All patients are needed to have written informed consent before enrolment in the study.
Exclusion criteria
Exclusion criteria: Patients are excluded (a)if they have already introduced maintenance HD before admission, (b)have got abdominal surgery for perforation of digestive tract, (c)have fallen in sepsis for more than 48 hours before the start of antibiotic therapy, (d)can't get out of septic shock within 72 hours after the start of antibiotic therapy, (e)have severe chronic heart failure as NYHA III or IV, (f)known pregnancy, (g)expected stay in the intensive care unit of less than 3 days, or (h)poor chance of survival.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| Renal function Introduction of maintenance haemodialysis (HD) Ventilator free days 90-day mortality | — |
Countries
Japan
Outcome results
None listed