Effect of recombinant thrombomodulin (ART123) for sepsis with disseminated intravascular coagulation

Effect of recombinant thrombomodulin (ART123) for sepsis with disseminated intravascular coagulation - Effect of rTM for sepsis with DIC

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003799

Enrollment

Registered

2010-07-01

Start date

2010-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

severe sepsis, septic shock, sepsis with disseminated intravascular coagulation

Interventions

administration of recombinant thrombomodulin administration of saline

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: svere sepsis and septic shock with acute DIC score more than 4 points

Exclusion criteria

Exclusion criteria: hemorrhagic complication pregnant

Design outcomes

Primary

Measure	Time frame
28-day mortality hemorrhagic event	—

Secondary

Measure	Time frame
28-day ICU mortality SOFA score data of coagulation (platelet, PT-INR, fibrinogen, FDP, TAT, PIC, ATIII, protein C, protein S) data of inflammation (CRP, procalcitonin, IL-1beta, IL-6, TNF-alfa, HMGB1) resolution rate of JAAM DIC score weaning rate of mechanical ventilator	—

Countries

Japan

Contacts

Public ContactToshiki SERA

Tokyo Medical and Dental University Medical Hospital Shock, Trauma, and Critical Care Center

seraaccm@tmd.ac.jp03-5803-5102

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026