pancreatic cancer
Conditions
Interventions
preoperative chemoradiotherapy with 1 course of S-1
preoperative chemoradiotherapy with 2course of S-1
Sponsors
Wakayama Medical University, School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Confirmed boarder-line resectable pancreatic cancer as adenocarcinoma by histological, cytological, or radiological examinations 2)Confirmed target region 3)No prior treatment 4)Age 20-80 5)PS 0/1 6)Adequate organ functions neutrophils >=1,500/mm3 leukocytes >=4,000/mm3, =<12,000/mm3 platelets >=100,000/mm3 hemoglobin >=10.0g/dL AST(GOT)/ALT(GPT)/ALP within 3 times of normal limits total bilirubin <=1.5mg/dL BUN <= 25mg/dl serum creatinine <=1.5mg/dL creatinine clearance >=50mL/min 6)PS(ECOG) 0-2 7)Sufficient oral intake 8)With written informed consent 9)Estimated life expectancy of at least 3 months
Exclusion criteria
Exclusion criteria: 1)Active double cancer 2)Severe diarrhea 3)Symptomatic pulmonary fibrosis or interstitial pneumonia. Marked pleural or peritoneal effusion 4)Metastasis in central nervous system 5)para-aortic lymph node metastasis 6)Severe complications, such as ileus, heart failure and renal failure 7)Pregnant females, possibly pregnant females, females wishing to become pregnant and nursing mothers. Males that are currently attempting to produce a pregnancy 8)History of severe anaphylaxies 9)Active infection 10)Severe mental disorder 11)Patients under treatment with flucytosine, phenytoin or warfarin potassium 12)Inadequate physical condition, as diagnosed by primary physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety,Efficacy | — |
Countries
Japan
Contacts
Public ContactMasaji Tani
Wakayama Medical University, School of Medicine Second Department of Surgery
Outcome results
None listed