A randomized comparison of chemically assisted ESD with submucosal injection of mesna and standard ESD.

A randomized comparison of chemically assisted ESD with submucosal injection of mesna and standard ESD. - A RCT of CA-ESD using mesna and standard ESD.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003786

Enrollment

100

Registered

2010-06-21

Start date

2010-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early gastric cancer

Interventions

Using mesna as a submucosal injection solution Using saline as a submucosal injection solution

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Gastric neoplasias with indications of ESD

Exclusion criteria

Exclusion criteria: History of hypersensitivity to mesna and women who were pregnant, lactating, or hoping to become pregnant during this study period

Design outcomes

Primary

Measure	Time frame
Procedural time	—

Secondary

Measure	Time frame
Procedural success rate En bloc resection rate Complication and side effect rates The healing process of post therapeutic ulceration Histological analysis of chemical effect on sampled specimens	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026