Role of Prophylactic Antibiotics in Laparoscopic Cholecystectomy: A Prospective Randomized Study

Role of Prophylactic Antibiotics in Laparoscopic Cholecystectomy: A Prospective Randomized Study - Prophylactic antibiotics in laparoscopic cholecystectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003749

Enrollment

1000

Registered

2010-06-14

Start date

2007-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gallstone, Gallbladder polyp

Interventions

Antibiotic group: First generation cefem (1.0 g/body) is infused once intraoperatively and twice on postoperative day 1. No antibiotic group: No perioperative antibiotics are administered.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Candidate for laparoscopic cholecystectomy 2. No infectious disease including acute cholecystitis 3. No severe disease such as diabetes mellitus requiring insulin, renal failure with hemodialysis, etc. 4. No antibiotic administration within a week before operation 5. Provided written informed consent

Exclusion criteria

Exclusion criteria: 1. Switch to open surgery 2. Emergency surgery 3. Allergy to antibiotics 4. Obstructive jaundice

Design outcomes

Primary

Measure	Time frame
postoperative infection-related complications	—

Secondary

Measure	Time frame
postoperative hospital stay postoperative medical costs	—

Countries

Japan

Contacts

Public ContactYoichi Matsui

Kansai Medical University Department of Surgery

matsui@hirakata.kmu.ac.jp0728040101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026