The status of essential trace metals and the efficacy of zinc supplementation in depressive disorders

The status of essential trace metals and the efficacy of zinc supplementation in depressive disorders - A study of the efficacy of zinc supplementation in depressive disorders

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003706

Enrollment

Registered

2010-06-04

Start date

2009-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depressive disorders

Interventions

Administraion of polaprezinc, a zinc-containing product.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Those with depressive disorders according to DSM-IV-TR criteria, who are considered to be resistant to conventional antidepressant treatment.

Exclusion criteria

Exclusion criteria: Suicidal score in HAM-D17 is greater than 2.

Design outcomes

Primary

Measure	Time frame
Serum levels of elements Zn and Cu, albumin, and total protein. Body weight and HAM-D17 score. These will be measured at 0, 4, 8, 12 weeks.	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026