rectal cancer
Conditions
Interventions
Preoperative capecitabine with concurrent radiation therapy for locally advanced rectal cancer.
Sponsors
Wakayama Medical University, Second Department of Surgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Stage II and III respectable locally advanced rectal cancer confirmed with colonoscopy, endoscopic ultrasonography, computed tomography, and magnetic resonance imaging. 2. ECOG performance status: 0-2. 3. Age: 20-80. 4. White blood cells: 2000/mm3-15000/mm3, Platelet >7.5/mm3, GPT <150IU/L, T-bil <3.0g/dL. 5. patient providing informed consent.
Exclusion criteria
Exclusion criteria: 1. Stage IV rectal cancer, rectal cancer with bowel obstruction. 2. Pregnancy. 3. Lactation. 4. Pregnancy attempy. 5. Infectious diseases. 6. Use of immunosuppressive drug and steroid. 7. Double cancer. 8. Injury and wound. 9. Paralytic ileus and interstitial pneumonia. 10. Doctor's exclusion decision.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety Side effect including clinical symptoms and blood examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficacy Pathologic complete response rate, pathological downstaging, sphincter preservation, survival, local recurrence, urinary disorder, and anorectal disorder. | — |
Countries
Japan
Contacts
Public ContactShozo Yokoyama
Wakayama Medical University Second Department of Surgery
Outcome results
None listed