A comparison of twenty-four-hour blood pressure control between candesartan and other ARBs estimated by the ambulatory blood pressure monitoring

A comparison of twenty-four-hour blood pressure control between candesartan and other ARBs estimated by the ambulatory blood pressure monitoring - Effect of candesartan on 24-hours blood pressure control

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003684

Enrollment

Registered

2010-06-19

Start date

2010-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

essential hypertension

Interventions

Change ARB(except for candesartan) to candesartan.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with hypertension who are treated with ARB other than candesartan. Their blood pressure levels evaluated by ABPM do not achieve the goal of Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009).

Exclusion criteria

Exclusion criteria: 1. secondary hypertension 2. systolic blood pressure >160 mmHg and or diastolic blood pressure > 100 mmHg 3. malignant hypertension 4. history of stroke, myocardial infarction and other cardiovascular disease that needed hospitalization within recent 6 months. 5. atrial fibrillation 6. patients with fundal hemorrhage, exudation or papilledema due to hypertensive retinopathy 7. liver dysfunction(the levels of AST or ALT reached 250% of their upper normal limit.) 8. Renal dysfunction (serum creatinine > 2.0 mg/dl) 9. hyperkalemia (serum K > 5.5 mEq/l) 10. pregnant or nursing women 11. patients who are not recommended for participation in this study by physician in charge with medical reasons.

Design outcomes

Primary

Measure	Time frame
The difference of mean nocturnal blood pressure between candesartan and other angiotensin 2 receptor blockers.	—

Secondary

Measure	Time frame
The difference of mean 24-hour blood pressure between candesartan and other angiotensin 2 receptor blockers. The difference of mean morning blood pressure between candesartan and other angiotensin 2 receptor blockers. Percentage of the patient who achieved the target of 24-hour blood pressure in Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009).	—

Countries

Japan

Contacts

Public ContactOkura Takafumi

Ehime University Graduate School of Medicine Department of Integrated Medicine and Informatics

okura@m.ehime-u.ac.jp089-960-5302

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026