Patients with peripheral artery disease and hypercholesterolemia
Conditions
Interventions
intensive lipid lowering therapy with Pitavastatin, 1 to 4mg once daily, to achieve serum LDL cholesterol level less than 80mg/dl.
conventional lipid lowering therapy with Pitavastatin, 1 to 4mg once
Sponsors
The Second Department of Internal Medicine, University of Toyama, Graduate school of medicine and pharmaceutical science,
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patient without coronary artery disease, whose LDL cholesterol >= 120mg/dl 2) Patient with coronary artery disease, whose LDL cholesterol >= 100mg/dl 3) Ankle Brachial Pressure Index (ABI) <= 0.9
Exclusion criteria
Exclusion criteria: 1) Following "contraindication" or "essentially contraindication" of pitavastatin as follows: severe liver injury or biliary obstruction patients taking cyclosporin pregnant or possible pregnant women or breast-feeding women patients with renal dysfunction and taking fibrates 2) patients already taking pitavastatin 3) patients with maintenance dialysis 4) patients who plan to undergo or underwent bilateral lower limb revascularization within within 3 months. 5) patients with severe peripheral artery disease (Fontaine classification class 4) 6) patient with previous cerebral hemorrhage 7) patients who judged inadequate by the co-execution doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| claudication time on Treadmill exercise test | — |
Countries
Japan
Contacts
Public ContactTomoki Kameyama
University of Toyama Graduate school of medicine and pharmaceutical science, The Second Department of Internal Medicine
Outcome results
None listed