Prospective multicenter study on the quantitative pathophysiological assessment of acute pulmonary edema

Conditions

acute pulmonary edema

Tadashi Kaneko, Yoshikatsu Kawamura, Tsuyoshi Maekawa, Takashi Tagami, Toshiaki Nakamura et al. (25 authors)

Journal of Intensive Care2014-04-0118 citations

10.1186/2052-0492-2-25

Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study

Kenichiro Morisawa, Shigeki Fujitani, Yasuhiko Taira, Shigeki Kushimoto, Yasuhide Kitazawa et al. (25 authors)

Journal of Intensive Care2014-03-2531 citations

10.1186/2052-0492-2-24

Relationship between extravascular lung water and severity categories of acute respiratory distress syndrome by the Berlin definition.

Kushimoto S, Endo T, Yamanouchi S, Sakamoto T, Ishikura H, Kitazawa Y, Taira Y, Okuchi K, Tagami T, Watanabe A, Yamaguchi J, Yoshikawa K, Sugita M, Kase Y, Kanemura T, Takahashi H, Kuroki Y, Izumino H, Rinka H, Seo R, Takatori M, Kaneko T, Nakamura T, Irahara T, Saito N, PiCCO Pulmonary Edema Study Group.

2013-06-2057 citations

10.1186/cc12811

The clinical usefulness of extravascular lung water and pulmonary vascular permeability index to diagnose and characterize pulmonary edema: a prospective multicenter study on the quantitative differential diagnostic definition for acute lung injury/acute respiratory distress syndrome.

Kushimoto S, Taira Y, Kitazawa Y, Okuchi K, Sakamoto T, Ishikura H, Endo T, Yamanouchi S, Tagami T, Yamaguchi J, Yoshikawa K, Sugita M, Kase Y, Kanemura T, Takahashi H, Kuroki Y, Izumino H, Rinka H, Seo R, Takatori M, Kaneko T, Nakamura T, Irahara T, Saito N, Watanabe A, PiCCO Pulmonary Edema Study Group.

2012-12-1193 citations

10.1186/cc11898

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients ventilated (expected over 48 hours) for acute respiratory failure with P/F ratio <300 and bilateral infiltration on chest radiograph requiring transpulmonary thermodilution technique monitoring

Exclusion criteria

Exclusion criteria: 1) Over 5 days from the onset of acute respiratory failure with PaO2 /FIO2 ratio < 300 2) Chronic respiratory insufficiency (COPD, et al) 3) After pulmonary resection / pneumonectomy 4) Pulmonary thromboembolism 5) Severe peripheral arterial disease (ASO, et al) 6) Cardiogenic shock with cardiac index < 1.5 L/min/m2 7) Inappropriate for evaluation with transpulmonary thermodilution technique 8) Attending physician's decision for inappropriateness for inclusion

Design outcomes

Primary

Measure	Time frame
To establish the quantitative differential criteria of cardiogenic edema and ALI/ARDS (permeability edema), using pulmonary vascular permeability index (PVPI) and extravascular lung water index (ELWI).	—

Secondary

Measure	Time frame
1) Effects of serum albumin level and osmolarity on ELWI 2) Assessment of the relationship between PVPI and capillary leak index 3) Effect of selective neutrophil elastase inhibitor on patients with acute pulmonary edema 4) Assessment of severity and prognosis using ELWI, PVPI, and plasma antithrombin activity 5) Prognostic value of ELWI calculated from predicted body weight 6) Differences of EVLW and PVPI between direct and indirect injury 7) Relationship between serum BNP, NT-proBNP, creatinine and ELWI, PVPI. 8) Relationship between DIC and ELWI, PVPI 9) Relationship between ELWI, PVPI and 28-day mortarityl, period of time on mechanical ventilation. 10) Relationship between ELWI, PVPI measured at the onset of acute pulmonary edema and quasi-static lung compliance, PEEP level. 11)Relationship between procalcitonin, acutephase reactants and ELWI, PVPI	—

Measure

Time frame

1) Effects of serum albumin level and osmolarity on ELWI 2) Assessment of the relationship between PVPI and capillary leak index 3) Effect of selective neutrophil elastase inhibitor on patients with acute pulmonary edema 4) Assessment of severity and prognosis using ELWI, PVPI, and plasma antithrombin activity 5) Prognostic value of ELWI calculated from predicted body weight 6) Differences of EVLW and PVPI between direct and indirect injury 7) Relationship between serum BNP, NT-proBNP, creatinine and ELWI, PVPI. 8) Relationship between DIC and ELWI, PVPI 9) Relationship between ELWI, PVPI and 28-day mortarityl, period of time on mechanical ventilation. 10) Relationship between ELWI, PVPI measured at the onset of acute pulmonary edema and quasi-static lung compliance, PEEP level. 11)Relationship between procalcitonin, acutephase reactants and ELWI, PVPI

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Countries

Japan

Contacts

Public ContactShigeki Kushimoto, M.D.

Tohoku University Graduate School of Medicine Division of Emergency Medicine

kussie@emergency-medicine.med.tohoku.ac.jp022-717-7487

Outcome results