dementia
Conditions
Interventions
PET, MRI, Neuropsychological test
PET, MRI, Neuropsychological test
PET, MRI, Neuropsychological test
PET, MRI, Neuropsychological test
PET, MRI, NEuropsychological test
Sponsors
Nippon Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Subjects who have the ability to provide informed consent and adhere to the protocol. Normal controls: - Without past or current history of cognitive dysfunction - Mini-Mental State Exam score is 28 or more Alzheimer's disease: - Subject who meet the diagnostic criteria of Alzheimer's disease on International classification of Diseases 10th revision - Informed consents are obtained from patients and one of their family members Mild cognitive impairment: - Memory complaints by subject that is verified by a study partner - Objective cognitive impairment - General cognition and functional performance sufficiently preserved - Not meet the criteria of dementia Mental disorder with cognitive impairment Age-related macular degeneration
Exclusion criteria
Exclusion criteria: Exclusion criteria: - With past or current history of serious medical illness and/or brain organic diseases - Subject who is contraindicated for the use of MRI - With past or current history of severe liver disease, kidney disease, heart disease, allergy, or severe drug allergy - Subjects who are judged as not suitable for participation in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amyloid deposits and distribution in brain measured by positron emission tomography among patients and age-matched normal controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| To investigate the correlation between the cognitive function, brain MRI, and FDG-PET and amyloid deposits. | — |
Countries
Japan
Contacts
Public ContactAmane Tateno, M.D., Ph.D.
Nippon Medical School Department of Neuropsychiatry
Outcome results
None listed