Combined Assessment of Left Ventricular Dyssynchrony and Contractility for Predicting Response to Cardiac Resynchronization Therapy: Multicenter Evaluation of i-Index

Combined Assessment of Left Ventricular Dyssynchrony and Contractility for Predicting Response to Cardiac Resynchronization Therapy: Multicenter Evaluation of i-Index - MEIDEX

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000003596

Enrollment

150

Registered

2010-05-11

Start date

2010-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who are scheduled to undergo cardiac resynchronization therapy and filfull all of the following: 1.QRS duration>/=120ms 2.LVEF</=35% 3.NYHA class III or IV 4.Recieving appropreate medical therapy for heart failure including ACE-inhibitor or ARB and beta-blocke, unless contraindicated 4.Sinus rhythm or Right ventricular pacing (%ventricular pacing>90%)

Exclusion criteria

Exclusion criteria: 1. Inability to obtain informed consent 2. Age less than 20 3. Disqualification by attending physician 4. Incapable of follow-uo visits 5. Irregular ventricular response due to atrial arrhythmia 6. Intravenous inotropic drug therapy 7. unstable angina/acute myocardial infarction 8. Cardiac surgery including CABG and PCI within 3 months 9. CRT with more than or equal to three sites ventricular pacing

Design outcomes

Primary

Measure	Time frame
Relative reduction of left ventricular end-systolic volume of more than 15% at 6 months following initiation of cardic resynchronization therapy.	—

Secondary

Measure	Time frame
Clinical composite score	—

Countries

Japan

Contacts

Public ContactHiromi Asano

Medtronic Japan CRDM Nagoya Branch

052-220-6446

Outcome results