Effects of Statins on Left Ventricular Diastolic Function in Patients with Dyslipidemia and Diastolic Dysfunction

Effects of Statins on Left Ventricular Diastolic Function in Patients with Dyslipidemia and Diastolic Dysfunction - Stat-LVDF Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003571

Enrollment

Registered

2010-05-10

Start date

2010-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with left ventricular diastolic dysfunction as well as hypercholesterolemia

Interventions

Hydrophilic statin dose: according to Japan Atherosclerosis Sociaty Guideline duration: 24 weeks Hydrophobic statin dose: according to Japan Atherosclerosis Sociaty Guideline duration: 24 weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Echocardiography: EF>45%, E/A<1, Dct>=210msec 2. Total cholesterol<280mg/dL or LDL-C<200mg/dL 3. LDL-C levels are to be treated according to the guideline by Japan Atherosclerosis Society

Exclusion criteria

Exclusion criteria: 1. Statin treatment within 3 months 2. Possible change in treatment for hypertemnsion or chronic heart failure 3. Myocardial infarction in 1 month 4. Coronary angioplasty or bypass surgery within 1 month or possible coronary angioplasty or bypass surgery within 3 months 5. Active malignancy 6. Severe liver dysfunction 7. Serum creatinin > 2.0mg/dL 8. Steriod or immunosupressant use 9. Pregnancy or lactation

Design outcomes

Primary

Measure	Time frame
Diastolic dysfunction by Doppler echocardiography	—

Countries

Japan

Contacts

Public Contactkoji Hasegawa

National Hospital Organization Kyoto Medical Center Division of Translational Research

koj@kuhp.kyoto-u.ac.jp075-641-9161

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026