the study on the relationship between renin activity and hypotensive efficacy of uncombined angiotensin II receptor blockers(ARB) therapy and combined ARB+diuretic therapy for hypertension

the study on the relationship between renin activity and hypotensive efficacy of uncombined angiotensin II receptor blockers(ARB) therapy and combined ARB+diuretic therapy for hypertension - study of relationship between drug therapy with ARB and diuretic and renin activity

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003473

Enrollment

Registered

2010-04-09

Start date

2010-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertension

Interventions

telmisartan 40mg, 7days &gt

telmisartan 40mg+hydrochlorothiazide 12.5mg, 7days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. individuals with systolic blood pressure >=130mmHg and <180mmHg and/or diastolic blood pressure >=85mmHg and <110mmHg. 2. individuals who have not been received hypotensors except for Ca antagonists. 3. BMI: >=18kg/m2, <30kg/m2 4. individuals capable of understanding the study protocol and complying with the related instructions.

Exclusion criteria

Exclusion criteria: 1. secondary hypertension 2. individuals with serious complications 3. pregnant and lactating women

Design outcomes

Primary

Measure	Time frame
hypotensive effect renin activity	—

Countries

Japan

Contacts

Public ContactHiromitsu Imai

Oita university Faculty of medicine Dept of clinical pharmacology and therapeutics

imaih@oita-u.ac.jp097-586-5952

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026