Combination therapy with azelnidipine or trichlormethiazide added on olmesartan in hypertensive patients with glucose intolerance

Combination therapy with azelnidipine or trichlormethiazide added on olmesartan in hypertensive patients with glucose intolerance - Combination therapy with azelnidipine or trichlormethiazide added on olmesartan in hypertensive patients with glucose intolerance

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003459

Enrollment

Registered

2010-04-07

Start date

2009-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension with glucose intolerance

Interventions

olmesartan(5-40mg)+azelnidipine(8-16mg)day olmesartan(5-40mg)+trichlormethiazide(0.5-1.0mg)day

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: hypertensive outpatients with glucose intolerance 1)Among patients on Olmesartan blood pressure 130/80mmHg moreover blood pressure at home 125/75mmHg moreover 2)FBS 100mg/dl moreover HbA1c 5.2 moreover

Exclusion criteria

Exclusion criteria: 1)Among patients on azelnidipine or trichlormethiazide 2)Severe hepatic disease 3)Severe renal disease(During dialysis) 4)pregnancy or possibility of the pregnancy 5)posses hypersensitivity to azelnidipine or trichlormethiazide 6)Patients with insulin treatment or scheduling the insulin administration 7)FBS 100mg/dl moreover HbA1c 5.2 moreover 8)Patients who are inadequate to entry this study by physians in charge

Design outcomes

Primary

Measure	Time frame
Insulin sensitivity	—

Secondary

Measure	Time frame
Changes in blood pressure level at home after gettin up. Aggravation of the renal function. changes in urinary albumin level,albuminuria,eGFR. hsCRP,8-OHDG,uric acid,K, new onset of diabetes.	—

Countries

Japan

Contacts

Public ContactDaisuke Koya

Kanazawa Medical University Diabetes & Endocrinology

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026