Avian and swine influenza virus infection
Conditions
Interventions
Treatment with neuraminidase inhibitors plus macrolide antibiotics
Treatment with neuraminidase inhibitors without macrolide antibiotics
Sponsors
Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed as type A influenza infection. 2.Patients 16 years old and more, and high school students less than 16 years old. 3.Patients who understand the purpose of this study, and sign agreement forms.
Exclusion criteria
Exclusion criteria: 1. Patients with hypersensitivity to macrolide antibiotics. 2.Patients being treated with agents as follows: pimozide, and agents including ergotamine. 3.Patients judged inappropriate for the study by physicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The presence of nasal discharge and sputum after 5-days of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) The presence of cough 5 days after the treatment. 2) Duration or time of fever 38 degree centigrade or more. 3) Presence of complication with pneumonia. 4) Serum concentrations of inflammatory cytokines (interleukin-1, interleukin-6, TNF-alpha, TGF-beta) after 5-days of treatment. | — |
Countries
Japan
Contacts
Public ContactMutsuo Yamaya
Tohoku University Graduate School of Medicine Department of Advanced Preventive Medicine for Infectious Disease
Outcome results
None listed