Elective laparoscopic colorectal surgery
Conditions
Interventions
Daily administration of synbiotics both for more than 7 days before surgery and from 2 to 7 postoperaive days
Control (without placebo)
Sponsors
Nagoya Daini Red Cross Hospital
Yakult Central Institute for Microbiological Research
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients scheduled to undergo elective laparoscopic colorectal surgery in Nagoya Daini Red Cross Hospital
Exclusion criteria
Exclusion criteria: In case significant changes are needed in the planning of surgery (e.g. addition of hepatectomy or urinary tract diversion). Those who prefer to drink beverages of synbiotics or those who dislike such products. Those who have difficulty in taking water because of the diseases, such as bowel obstruction. Those who cannot understand the concept of the study (e.g. dementia or mental disorders). Patients who do not have enough time to take synbiotics products for more than 7 days before surgery (e.g. when the surgery should be scheduled as soon as possible after the admission.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of postoperative infectious complications | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma level of CRP after surgery Intestinal microflora attached to the epithelium of the resected specimen Intestinal microflora, pH, and organic acids in the feces or mucus Changes in the immune functions of the resected intestine | — |
Countries
Japan
Contacts
Public ContactShunichiro Komatsu
Nagoya Daini Red Cross Hospital Surgery
Outcome results
None listed