breast cancer after breast-preserving surgery
Conditions
Interventions
Accelerated radiation therapy (38.5 Gy/10 fr/ 2 weeks) for partial breat.
Sponsors
National Cancer Center Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1)clinical stage 0-2 breast cancer with 3 cm or less of histological tumor diameter 2) pathohistological comfirmed non-inasive carcinoma, invasive carcinoma, or specific type excluding squamous cell carcinoma 3)solitary tumor 4)20 years old or more 5) breast-preserving surgery with lumpectomy or segmental mastectomy 6) more than 5mm of surgical margins 7)inserted surgical clips in the surgical margin of the tumor 8)axillary lymph node dissection with level I or II, or histologically negative sentinel lymph nodes. allowance for no axillary dissection in DCIS 9) 3 and less axillary lymph nodes metastases 10) Performance status of 0-2. 11) Written informed consent.
Exclusion criteria
Exclusion criteria: 1) prior radiation therapy against the thoracic. 2) neoadjuvant chemotherapy and/or hormonal therapy 3) Infection with systemic therapy indicated. 4) Scleroderma, systemic lupus erythematosus, dermatomyositis 5) Women during pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency and severity of adverse events of radiotherapy | — |
Secondary
| Measure | Time frame |
|---|---|
| ipsilateral breast recurrence-free survival, relationship of recurrent site of breast and CTV, disease-free survival, overall survival, proportion of deterioration of breast cosmetic outcomes, | — |
Countries
Japan
Contacts
Public ContactYoshikazu Kagami
National Cancer Center Hospital Radiation Oncology Division
Outcome results
None listed