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Biological predictors of responsiveness to cognitive behaviour therapy for anxiety disorders, depression and bulimia nervosa: a randomised controlled trial.

Biological predictors of responsiveness to cognitive behaviour therapy for anxiety disorders, depression and bulimia nervosa: a randomised controlled trial. - A randomised controlled trial of cognitive behaviour therapy and biological predictors.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000003331
Enrollment
60
Registered
2010-04-01
Start date
2010-04-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

anxiety disorders, obsessive compulsive disorders, eating disorders, depression and related disorders

Interventions

Participants were randomly assigned to waiting list or individual CBT guided self-care supported by therapists. Therapists were regularly supervised by professional CBT psychiatrists or psychologists.

Sponsors

Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba
Lead Sponsor
Department of Integrative Neurophysiology Chiba University Graduate School of Medicine
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Participants were recruited at the Department of Psychiatry, Department of Child Psychiatry, Chiba University Hospital. Written informed consent was sought from participants. They were 7-75 years of age, met DSM-IV criteria for anxiety disorders, obsessive compulsive disorders, bulimia nervosa, depressive disorders and related disorders.

Exclusion criteria

Exclusion criteria: We excluded patients with a body mass index below 15, patients suffering from severe mental illness, or substance dependence, pervasive developmental disorders, learning disability, severe physical illness, at risk for self-injury or suicidal attempt, patients with GAF score below 50, mental retardation and mental disability (IQ<80).

Design outcomes

Primary

MeasureTime frame
Body mass index(BMI), frequency of binge-eating and purging behaviours,BITE,EDEQ,HADS,YBOCS

Secondary

MeasureTime frame
Wisconsin Card Sorting Test (WCST), Trail Making Test,Iowa Gambling Task(IGT),NIRS,p-50,serum brain-derived neurotrophic factor (BDNF), serum amino acids

Countries

Japan

Contacts

Public ContactMichiko Nakaztao

Chiba University Hospital Department of Child Psychiatry

nakazato@faculty.chiba-u.jp043-226-2297

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026