Search for optimum dose and timing of tranexamic acid administration in cardiac surgery with cardiopulmonary bypass.

Search for optimum dose and timing of tranexamic acid administration in cardiac surgery with cardiopulmonary bypass. - Search for optimum dose and timing of tranexamic acid administration in cardiac surgery with cardiopulmonary bypass.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003327

Enrollment

140

Registered

2010-03-13

Start date

2010-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiac insufficiency requiring surgery (for the patients undergoing cardiac surgery with cardiopulmonary bypass)

Interventions

Group of NORMAL DOSE BEFORE CPB a)30mg/kg b)16mg/kg/h c)2mg/kg d)NS (CPB: cardiopulmonary bypass, NS: normal saline) a) loading dose before CPB b) maintenance dose after loading (5 hours) c)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients undergoing cardiac surgey (coronary artery bypass graft or valvular replacement) with normothermic cardiopulmonary bypass.

Exclusion criteria

Exclusion criteria: urgent/emergency operation, sepsis, infectious endocarditis, using IABP, renal insufficiency (Cre>2.0), active hepatitis, platerets<50000, preoperative hemostatic abnormality, continuous anticoagulant therapy, therapy with self blood, therapy with thrombin, allergy with taranexamic acid, patients recognised as inadequate for the study.

Design outcomes

Primary

Measure	Time frame
blood loss in 24 hours after surgery	—

Secondary

Measure	Time frame
intraoperative blood loss intraoperative transfusion blood loss in 6 hours after surgery blood loss in 12 hours after surgery total blood loss after surgery transfusion after surgery hemostatic variavles before and after culdiopulmonary bypass cytokines before and after culdiopulmonary bypass postoperative complications duration of mechanical ventilation duration of intensive care unit stay	—

Countries

Japan

Contacts

Public ContactToshinori Horiuchi

Bellland General Hospital Department of Anesthesia

t_horiuchi@seichokai.or.jp072-234-2001

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026