The effect of synbiotics in protecting infectious complications following surgeries for esophageal and gastric cancer.

The effect of synbiotics in protecting infectious complications following surgeries for esophageal and gastric cancer. - The effect of synbiotics in protecting infectious complications following surgeries for esophageal and gastric cancer.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003262

Enrollment

Registered

2010-02-28

Start date

2008-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

surgical cases of esophageal cancer and gastric cancer that need open chest procedure

Interventions

Yakult 400 (Yakult Honsha, Tokyo, Japan) Bifiene S (Yakult Honsha) galactooligosaccharides (Oligomate S-HP, Yakult Honsha

15 g/day) Control: no treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients with esophageal and gastric cancer who fulfilled the criteria of this study and agreed with the enrollment in this study

Exclusion criteria

Exclusion criteria: patients who reject to be enrolled in this study patients who do not fulfill the criteria of this study

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative infectious complications/ Surgery-related mortality/ In hospital days	—

Secondary

Measure	Time frame
Inflammatory response by blood test Bacterial translocation during operation confirmed by the analysis of mesenteric lymph nodes. Incidence of postoperative bacteremia.	—

Countries

Japan

Contacts

Public ContactMasahide Fukaya

Nagoya University Graduate School of Medicine Division of Surgical Oncology, Department of Surgery

nagino@med.nagoya-u.ac.jp0527442218

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026