A longitudinal study about Xylitol, its influence and preventive effectiveness on mutans streptococci and Streptococcus pneumoniae

A longitudinal study about Xylitol, its influence and preventive effectiveness on mutans streptococci and Streptococcus pneumoniae - Effect of Xylitol on oral bacteria

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003112

Enrollment

400

Registered

2010-01-28

Start date

2001-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dental caries, otitis media

Interventions

The children in Xylitol gum group were instructed to chew 1 gum pellet (100% xylitol gum) at least 4 times per day for three months (from months 6 to 9). The children in control group were to be untre

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: We examined children who attended preschools in Tokyo, Japan. The preschools were within 2 km of one another.

Exclusion criteria

Exclusion criteria: Individual with a history of regular antibiotics medication or habitual xylitol gum consumption.

Design outcomes

Primary

Measure	Time frame
Dentocult SM score development in the children observed at 0 and 6, and 9 months after the baseline survey.	—

Secondary

Measure	Time frame
PCR detection for Streptococcus pneumoniae in the children observed at 0 and 6, and 9 months after the baseline survey. .	—

Countries

Japan

Contacts

Public ContactMitsuko Seki

Nihon University School of Dentistry Oral Health Sciences

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026