Hpercholesterolemic patients with impaired glucose tolerance or moderate type 2 diabetes
Conditions
Interventions
Pravastatin 10mg daily for 6 months
Pitavastatin 2mg daily for 6 months
Pitavastatin 4mg daily for 6 months
Sponsors
Kanazawa University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who 1)are at age of 18 to 80 years at time of consent, male or female 2)are impaired glucose tolerance by 75g oral glucose tolerance test (2-h plasma glucose 140-199 mg/dl) 3)are mild diabetes mellitus by HbA1c<7.0% 4)have Hypercholesterolemia with level of serum LDL-C>/= 140mg/dL(by Friedwald formula of by direct method in the case of patients with level of serum TG 400mg/dl) 5)provide written informed concent for participation in the study
Exclusion criteria
Exclusion criteria: Patients who 1)have taken statins or are with the use of statins within 4 weeks 2)have severe hypertension (SBP>= 160 mmHg or DB` >= 100 mmHg) 3)have uncontrolled glucose metabolism(change of Hba1c >2%) 4)are judged as being inappropriate for this study by their own doctors 5)are judged as being inappropriate for this study by investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of influence on glucose metabolism among 3 groups and that of linkage between LDL-C and glucose metabolism | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) A change of influence on glucose metabolism 2) A change of LDL-C 3)Comparison of efficacy among 3 groups | — |
Countries
Japan
Outcome results
None listed