Phase II study of pre-operative chemoradiation using S-1 followed by surgical resection for potentially resectable and locally advanced pancreatic cancer

Phase II study of pre-operative chemoradiation using S-1 followed by surgical resection for potentially resectable and locally advanced pancreatic cancer - Phase II study of pre-operative chemoradiation for pancreatic cancer

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000003088

Enrollment

Registered

2010-01-26

Start date

2008-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Potentially resectable and locally advanced pancreatic cancer

Interventions

To investigate the frequency of histological (surgical) curative resection following chemoradiation using S-1in patients with potentially resectable and locally advanced pancreatic cancer.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Histo-cytologically confirmed pancreatic cancer radiographically defined as potentially resectable and locally advanced

Exclusion criteria

Exclusion criteria: 1) Patients with other active cancers 2) Patients with watery diarrhea 3) Intractable pleural and pericardical effusion, or ascites 4) Severe co-morbid diseases 5) Pregnancy or insufficient contraception 6) Past history of severe drug-allergy 7) Active bacterial or viral infection 8) younger than 20 years old or older than 90 years old. 9) No written informed consent of the patients 10) Pregnancy or insufficient contraception 11) HIV infection 12) Doubtful understanding or contractual capacity of the patient 13) Patients seems inadequate for this study by investigator(s)

Design outcomes

Primary

Measure	Time frame
Frequency of histological curative resection or surgical curative resection	—

Secondary

Measure	Time frame
Response rate of chemoradiation therapy Grading of histological response of chemoradiation therapy Safety of chemoradiation followed by surgical resection Operative mortality and morbidity	—

Countries

Japan

Contacts

Public ContactSohei SATOI M.D.

Kansai Medical University, Hirakata hospital Department of surgery

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026