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Effects of branched-chain amino acids support in patients undergoing radiofrequency ablation for hepatocellular carcinoma: a randomized controlled study

Effects of branched-chain amino acids support in patients undergoing radiofrequency ablation for hepatocellular carcinoma: a randomized controlled study - Effects of branched-chain amino acids support in patients undergoing radiofrequency ablation for hepatocellular carcinoma: a randomized controlled study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000003085
Enrollment
80
Registered
2010-02-01
Start date
2012-01-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hepatocellular carcinoma

Interventions

The patients in the BCAA group received BCAA orally administration before tumor ablation therapy until 1 month after the therapy. The patients in the diet group received diet therapy with defined dail

Sponsors

Yokohama City University Medical Center Gastroenterological Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1)Early-stage hepatocellular carcinoma(BCLC staging) 2)Compensated liver cirrhosis 3) Equal to or more than 20 years old.

Exclusion criteria

Exclusion criteria: Exclusion criteria are the presence of any one of the following: serum albumin <2.5mg dL, serum total bilirubin level <3mg/dL, hepatic encephalopathy of or above grade II, history of albumin infusion or receiving BCAA granules in the preceding 3 months, and bleeding varices.

Design outcomes

Primary

MeasureTime frame
Short- to mid-term effects of liver function and nutrition status during the post ablative period.

Secondary

MeasureTime frame
Time to tumor progression

Countries

Japan

Contacts

Public ContactManabu Morimoto

Yokohama City University Medical Center Gastroenterological Center

morimoto@urahp.yokohama-cu.ac.jp045-261-5656

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026