Refractory viremia with high viral load, viral infection and viral disease after allogeneic hematopoietic stem cell transplantation
Conditions
Interventions
Intravenous immunoglobulin(400mg/kg/day) for 5 days.
Sponsors
Hematology, Osaka City University, Graduate School of Meicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with hematological disease who received allogeneic hematopietic stem cell transplantation and meet the following criteria. 1) Ganciclovir or foscavir-resistant CMV infection or disease. 2) Aciclovir or valaciclovir-resistant HSV, VZV infection or disease. 3) Refractory adenovirus-associated hemorrhagic cystitis 4) Viral pneumonia 5) Viral gastroenteritis 6) Viral hepatitis 7) Viral encephalitis and meningitis 8) The following viremias with clinical symptom [1]EBV [2]HHV-6 [3]ADV [4]Ganciclovir or foscavir-resistant CMV viremia [5]Aciclovir or valaciclovir-resistant HSV, VZV viremia [6]parvovirus B19
Exclusion criteria
Exclusion criteria: 1) History of allergic reaction to immunoglobulin preparations 2) History of severe adverse effect of immunoglobulin preparations 3) Presence of veno-occlusive disease (VOD) after allogeneic stem cell transplantation 4) Positivity of HIV-antibody, HCV-antibody, HBs-antigen, or HBV-DNA 5) No indication for this study judged by physician in charge
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cure rate of viremia and virus disease | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Reduction of viral load 2)Degree of improvement in clinical symptoms, imaging findings and clinical laboratory test results | — |
Countries
Japan
Contacts
Public ContactMika Nakamae
Osaka City University, Graduate School of Medicine Hematology(Clinical center for hematological malignancies )
Outcome results
None listed