Acute Cardiogenic Pulmonary Edema
Conditions
Interventions
Continuous infusion of carperitide at 0.025 microg/kg/min for 72 hours
Continuous infusion of isosorbide dinitrate (ISDN) at 0.5 microg/kg/min for 72 hours
Sponsors
Cardiovascular Division, Hyogo College of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Pulmonary edema on admission 2)Dyspnea as a chief compliant 3)Systolic blood pressure >100mmHg 4)Patients providing written consent for participation in this clinical trial on their own volition after receiving a thorough explanation of the study
Exclusion criteria
Exclusion criteria: 1)Systolic blood pressure <100mmHg 2)Patients on hemodialysis 3)Patients with acute coronary syndrome 4)Patients with a history of hypersensitivity to any of the components of the product 5)Patients who are judged by the principal investigator to be ineligible for enrollment in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in serum creatinine, BUN and cystatin C levels from the admission value to discharge and/or day 7 of hospitalization | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in serum neuroholmonal factor (catecholamine, renin, angiotensin II, aldosterone and vasopressin) levels before and at 15, 30, 60, and 180 minutes after administration of vasodilators | — |
Countries
Japan
Contacts
Public ContactKenichi Fujii
Hyogo College of Medicine Cardiovascular Division
Outcome results
None listed