A clinical trial of proton radiotherapy with local immunotherapy for recurrent cases with hepatocellular carcinoma

A clinical trial of proton radiotherapy with local immunotherapy for recurrent cases with hepatocellular carcinoma - Proton radiotherapy and immunotherapy for hepatic cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002863

Enrollment

Registered

2016-12-31

Start date

2009-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular Carcinoma

Interventions

Proton radiotherapy Tumor immunotherapy by a novel adjuvant

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Recurrent cases with locally advanced hepatocellular carcinoma Life expectency is 6 months or more. Proton radiotherapy is indicated. KPS is 60% or more. Hepatic function is preserved.

Exclusion criteria

Exclusion criteria: Initially diagnosed case History of having other malignancies Having autoimmune disorders HIV positive Uncontrollable complications such as infections, heart disorders or psychiatric disorders Administration of anticancer drugs or corticosteroids within 4 months Pregnant Tuberculosis, or hyperreaction in DTH test with the advant

Design outcomes

Primary

Measure	Time frame
Safety Prevention of recurrence	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026