Patients undergoing elective hepatocellular carcinoma surgery
Conditions
Interventions
Flomoxef Sodium is administered afetr the induction of anesthesia, and the patients recieved an additional dose if the operation was prolonged beyond 3 hour, and cefmetazole was administered agin twic
Sponsors
Randomized clinical trial committee, Japan Society for Surgical Infection
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Hepatocellular carcinoma patients undergoing liver resection Liver damage A ECOG Performance Status Scale:0-2 Written informed consent.
Exclusion criteria
Exclusion criteria: Laparoscopic surgery Thoracotomy Digestive organ or vessel reconstruction Other organ resection. Those with cardiac dysfunction, renal dysfunction, Those who received insulin or steroid therapy. Those who were allergic to cefem or penicillin, pregnant, received antibiotic treatment in the past 2 weeks, had an infection at the time of surgery. A woman who is pregnant, lactating, or may become pregnant. ASA score >3. Exclude the patients who are recognized as inadequate patients by doctors with responsibility in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is to show that a 24 hours antibiotic administarion of the end of the operation was not inferior to the 3 days antibiotic administration of the postoperative period . | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome is to investigate the incidence of remote infection in each group. | — |
Countries
Japan
Contacts
Public ContactMasato Kusunoki
Japan Society for Surgical Infection Chairman of randomized clinical trial committee
Outcome results
None listed