tuberous sclerosis complex
Conditions
Interventions
Application of 0.2% Rapamycin ointment (ointment base is 0.03% tacrolimus ointment) on skin lesion of one side of the face twice a day for 12 weeks. Application of ointment base (control) on similar
Sponsors
Department of Dermatology Graduate School of Medicine, Osaka University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with a diagnosis of tuberous sclerosis complex made based on the clinical diagnostic criteria in guideline of Japanese Dermatological Association. 2) Patients who want to receive treatment for skin lesions of tuberous sclerosis complex. 3) Patients who cannot receive other effective treatment. 4) Patients who would not want to receive surgical treatment because of social circumstances or cosmetic reasons.
Exclusion criteria
Exclusion criteria: 1) Patients with severe mental retardation who cannot carry out this treatment plan. 2) Patients with a past history of hypersensitivity to macrolide antibiotics. 3) Patients who were judged unsuitable for this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in color and size of the skin lesions after 12 weeks topical treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| change in shape appearance of contact dermatitis rapamycin levels in whole blood | — |
Countries
Japan
Contacts
Public ContactMari Wataya-Kaneda
Graduate School of Medicine, Osaka University Department of Dermatology
Outcome results
None listed