Breast Cancer
Conditions
Interventions
* For patients identified as low risk by both MammaPrint and conventional method, no adjuvant chemotherapy will be applied. * For patients identified differently by MammaPrint and conventional method
Sponsors
Department of Breast and Endocrine Surjery, Juntendo University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age between 20 to 75 2. ECOG performance status 0-1 3. Cardiac: Ejection fraction ≥ 60% is needed (estimated by echocardiography) 4. Hepatic: AST & ALT ≤*2.5 upper normal limit, Total bilirubin ≤2.0 mg/dL 5. Invasive breast cancer, Stage I & II, by core needle biopsy 6. Lymph node negative patient (N0) by palpation and by ultrasound 7. Tumor size ≥1.5 cm (preferably ≥2.0 cm) 8. Able to collect fresh samples (No formalin fixation) 9. Able and willing to give valid written informed consent 10. No complication
Exclusion criteria
Exclusion criteria: 1. Developed malignancy except carcinoma in situ 2. Received Neo-adjuvant therapy treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation to decide breast cancer adjuvant therapy and treatment by applying MammaPrint to each patient to see if prognosis by gene expression profiling. | — |
Countries
Japan
Outcome results
None listed