Myocardial ischemia treated with PCI and coronary plaque regression induced by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography

Myocardial ischemia treated with PCI and coronary plaque regression induced by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography - Myocardial ischemia treated with PCI and coronary plaque regression induced by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002829

Enrollment

100

Registered

2010-02-10

Start date

2010-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with coronary artery disease accompanied with hypertension and hypercholesterolemia treated with percutaneous coronary intervention

Interventions

Intervention 1:aggressive intervention(target blood pressure&lt

120/70mmHg, target LDL-C&lt

70mg/dl) starting dose of atorvastatin 10mg starting dose of amrodipine 5mg Intervention 2:standard intervention(target blood pressure&lt

140/90mmHg, target LDL-C&lt

100mg/dl) starting dose of atorvastatin 5mg starting dose of amrodipine 2.5mg 18 months

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Hypercholesterolemia(greater than 100mg/dl)(with or without hypolipidemic drug therapy) Successful PCI At least 1 coronary plaque except for target lesion for PCI

Exclusion criteria

Exclusion criteria: Unsuccessful PCI Cardiogenic shock Type 1 diabetes mellitus Diabetes mellitus under insulin injection therapy or poor control Secondary hypertension Dihydropyridine Calcium channel blocker user for more than 6 months Statin user stronger than 10 mg daily of atorvastatin (pitavastatin, rosuvastatin) Familial hypercholesterolemia

Design outcomes

Primary

Measure	Time frame
The changes of coronary plaque volume	—

Countries

Japan

Contacts

Public ContactMasa-aki Kawashiri

Kanazawa University Graduate School of Medicine Division of Cardiovascular Medicine

mk@med.kanazawa-u.ac.jp076-265-2251

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026