Effects of anesthetics on intraoperative cerebral oxygen balance and postoperative cognitive outcome in patients undergoing lung surgery

Effects of anesthetics on intraoperative cerebral oxygen balance and postoperative cognitive outcome in patients undergoing lung surgery - COCOLUS (Cerebral oxygenation and cognitive outcome for lung surgery)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002826

Enrollment

200

Registered

2009-12-02

Start date

2007-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung surgery

Interventions

propofol sevoflurane

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients scheduled for elective lung surgery with ASA physical status 1-3

Exclusion criteria

Exclusion criteria: 1) pumonary fibrosis, 2) pregnant or possibility of pregnant, 3)psychological disorder, 4) Mini-Mental State Examination < 24, 5)moderate liver or renal dysfunction, 6) coagulation disorder

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative cognitive dysfunction	—

Secondary

Measure	Time frame
Intraoperative cerebral oxygen balance	—

Countries

Japan

Contacts

Public ContactJunji Egawa

Nara Medical University Department of Anesthesiology

jun.e@f7.dion.ne.jp0744-22-3051

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026