Effectiveness of citric acid in treating nocturnal muscle cramps: a randomized, double-blind, placebo-controlled trial

Effectiveness of citric acid in treating nocturnal muscle cramps: a randomized, double-blind, placebo-controlled trial - Effectiveness of citric acid in muscle cramps

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002804

Enrollment

Registered

2009-12-01

Start date

2008-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nocturnal muscle cramps

Interventions

Citric acid for 30 days -&gt

(washout period for 14 days) -&gt

Placebo for 30 days Placebo for 30 days -&gt

Citric acid for 30 days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Experiencing nocturnal muscle cramps more than two times a week

Exclusion criteria

Exclusion criteria: (1)Those who have diseases that are known to cause muscle cramps: anemia, diabetes mellitus, liver disease, kidney disease, and thyroid disease (2)Those who are taking medications that are known to cause muscle cramps (beta-stimulants,diuretics, HMG-CoA reductase inhibitors, cimetidine, lithium,morphine, nifedipine,penicillamine,and steroids)

Design outcomes

Primary

Measure	Time frame
Frequency of nocturnal leg muscle cramps	—

Countries

Japan

Contacts

Public ContactMayumi TanakaMD,PhD,MPH

St.Luke's International Hospital General Internal Medicine

mytanaka@luke.or.jp03-3541-5151

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026