chronic obstructive pulmonary disease
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: The inclusion criteria were outpatients with COPD in the 2nd (moderate) to 4th COPD stage (very severe) , who stably used inhaled tiotropium bromide for more than 6 months.
Exclusion criteria
Exclusion criteria: 1) present smokers and ex-smokers within 1 year, 2) treatment with other SABAs in the previous 3 months, 3) treatment with oral or intravenous corticosteroids in the previous 3 months, 4) new induction of home oxygen therapy (HOT) in the previous 6 months, 5) other chronic respiratory disease, 6) taking medication for chronic respiratory infectious diseases, 7) severe hepatic, heart or renal disease, hematologic diseases or other grave complications, 8) history of poor drug compliance, and 9) inappropriate from the doctor's perspective.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| dyspnea symptom score QOLs | — |
Secondary
| Measure | Time frame |
|---|---|
| pulmonary function tests impulse oscillometry system (IOS) | — |
Countries
Japan
Contacts
Tohno-Kousei Hospital Dept. of Allergy and Respiratory Medicine