Cardiovascular Disease
Conditions
Interventions
Lowering low-density lipoprotein with rousvastatin under 100mg/dl according to Japan Atherosclerosis Society Guidelines
Lowering low-density lipoprotein with atorvastatin under 100mg/dl according to J
Sponsors
Division of Cardiology, Health Insurance Hitoyoshi General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)stable cardiovascular disease patients 2)subjects who gave written informed consent
Exclusion criteria
Exclusion criteria: 1)history of side effect in statin therapy 2)impossible to exercise 3)history of allergy against other drugs 4)history of low pulmonary function and lung disease 5)history of severe hepatic and renal disturbance 6)Pregnant 7)poor compliance of medication 8)subjects whose doctor in charge do not agree to join the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum lipids (Triglyceride, high-density lipoprotein, low-density lipoprotein) at 4 and 20weeks after randomization | — |
Secondary
| Measure | Time frame |
|---|---|
| Parameter of glycolipid and inflammation, Metabolic Marker, Assessment of cardiac function by echocardiography, Assessment of arterial stiffness by PWV/ABI, Assessment of exercise and cardiopulmonary function by cardiopulmonary exercise testing | — |
Countries
Japan
Contacts
Public ContactKensuke Toyama
Graduate School of Medical Science, Kumamoto University Department of Cardiovascular Medicine
Outcome results
None listed